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Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - K 0859

K 0859

CAS No. 890129-26-7

K 0859( NVP-BGG463 )

Catalog No. M19234 CAS No. 890129-26-7

BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    K 0859
  • Note
    Research use only, not for human use.
  • Brief Description
    BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
  • Description
    NVP-BGG463 is a novel Type II kinase inhibitor, targeting CDK2.
  • In Vitro
    BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML.
  • In Vivo
    ——
  • Synonyms
    NVP-BGG463
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    c-ABL-T334I|Abl|Abl (T315I)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    890129-26-7
  • Formula Weight
    578.6
  • Molecular Formula
    C30H29F3N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL; 216.05 mM
  • SMILES
    CC(=O)Nc1cc(ncn1)Oc2ccc3c(c2)cccc3C(=O)Nc5ccc(CN4CCN(C)CC4)c(c5)C(F)(F)F
  • Chemical Name
    6-(6-Acetylamino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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