Cart
sales@molnova.com
K 0859
CAS No. 890129-26-7
K 0859( NVP-BGG463 )
Catalog No. M19234 CAS No. 890129-26-7
BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 71 | In Stock |
|
| 5MG | 110 | In Stock |
|
| 10MG | 178 | In Stock |
|
| 25MG | 332 | In Stock |
|
| 50MG | 478 | In Stock |
|
| 100MG | 691 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameK 0859
-
NoteResearch use only, not for human use.
-
Brief DescriptionBGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
-
DescriptionNVP-BGG463 is a novel Type II kinase inhibitor, targeting CDK2.
-
In VitroBGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML.
-
In Vivo——
-
SynonymsNVP-BGG463
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
Recptorc-ABL-T334I|Abl|Abl (T315I)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number890129-26-7
-
Formula Weight578.6
-
Molecular FormulaC30H29F3N6O3
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 125 mg/mL; 216.05 mM
-
SMILESCC(=O)Nc1cc(ncn1)Oc2ccc3c(c2)cccc3C(=O)Nc5ccc(CN4CCN(C)CC4)c(c5)C(F)(F)F
-
Chemical Name6-(6-Acetylamino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
BI-749327
BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
-
Vanilloid receptor a...
Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist.
-
TRPC6-PAM-C20
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
